Using mice to test CBD hepatotoxicity, researchers found that people using CBD could be at an elevated risk for liver toxicity. In clinical trials, 5% to 20% of the patients developed elevated liver enzymes." Essentially suggesting that Epidolex has the potential to lead to liver disease.
CBD is also believed to demonstrate anti-inflammatory properties that might help lessen the effects of clogged up sinus passages and might make it easier to breathe. THC activates the CB1 and CB2 receptors, while CBD does not directly stimulate these receptors.
In other studies, CBD oil was found to affect platelets and anticoagulants by suppressing their production and thereby potentially increasing bleeding tendencies. CBD is metabolized through the hepatic P450 enzyme system, which warfarin also uses.
Cannabidiol shows promise against superbug infections. Smoking marijuana is believed to reduce the body's ability to fight infections. But cannabidiol (CBD), a compound extracted from cannabis, might work as a powerful antibiotic against certain drug-resistant bacteria, scientists in Australia have found.
According to a study, acute cannabidiol or CBD administration suppresses irregular heartbeat caused by an inadequate blood supply in the heart or ischemia-induced heart arrhythmias. In the said study, irregular heartbeats were observed during ischemia (reduced blood flow) before CBD perfusion periods.